Multiple myeloma genome unveiled
Scientists have unveiled the most comprehensive picture to date of the full genetic blueprint of multiple myeloma, a form of blood cancer. A study of the genomes from 38 cancer samples has yielded new and unexpected insights into the events that lead to this form of cancer and could influence the direction of multiple myeloma research. This work, led by Harvard-affiliated scientists at the Broad Institute and Dana-Farber Cancer Institute, appears in the March 24 issue of Nature.Multiple myeloma is the second most common blood cancer in the United States, and about 20,000 new cases are diagnosed in this country every year. The disease’s five-year survival rate is less than 40 percent, which is low compared with other forms of cancer. Multiple myeloma begins in the bone marrow, where plasma cells (a type of white blood cell) become malignant, crowding out normal cells and attacking solid bone. No one knows the cause of the disease — it can develop in people with no known risk factors and, in many cases, no family history of multiple myeloma.The emerging genomewide picture of multiple myeloma reveals genes never before associated with cancer as well as multiple genetic mutations that disrupt just a handful of common pathways, or chains of chemical reactions that trigger a change in a cell. Individually, each of these mutations is fairly uncommon and might have remained undiscovered had the researchers not looked at such a large collection of samples.“Already, we can see that mutations are funneling into a limited number of pathways,” said co-senior author Todd Golub, director of the Broad’s Cancer Program and Charles A. Dana Investigator in Human Cancer Genetics at the Dana-Farber Cancer Institute. “This is a demonstration of the value of looking at more than just a single tumor in great depth.”Never before have scientists taken an in-depth look at so many multiple myeloma samples. Over the past six years, next-generation sequencing technologies — machines that can sequence DNA at a rapid pace and deliver massive amounts of data in a short period of time — have surged. Sequencing the full genome of a tumor is still a feat of technical and analytical prowess and only a few studies to date have looked across more than one. The team of researchers studied 38 multiple myeloma patients, comparing the patients’ normal genomes to the genomes from their malignant cells.With the whole cancer genome in view, one of the most challenging aspects of multiple myeloma research now is separating so-called driving events — the important mistakes that drive cells toward becoming cancerous — from passenger mutations, genetic alterations that are merely along for the ride. A team of researchers led by co-senior author Gad Getz, director of Cancer Genome Analysis at the Broad Institute, has developed computational tools to address this.“Next-generation sequencing has the great potential and promise to allow us to comprehensively analyze the cancer genome at extremely high resolution and see all of the events that happen in cancer,” said Getz. “These tools that we’ve developed are state of the art — we’ve been able to dramatically decrease the error rate for detecting all types of mutations. Now, we can find those genes whose mutations occur more than expected by chance.”The researchers found sets of mutations affecting many genes in the same pathways, including the NF-kB pathway. If this pathway is turned on at the wrong time, it can activate genes that allow a cancer cell to grow and divide unchecked. Previously, multiple myeloma researchers had suspected that this pathway was involved in the cancer’s development, but it was unclear exactly what events were turning this pathway on. In this latest study, the researchers discovered 11 different genes involved in this pathway that were altered in at least one multiple myeloma sample.Additionally, the study has brought to light new mutations affecting genes that had never previously been tied to cancer. “These genes, which are frequently mutated, were not on anyone’s radar before when thinking about multiple myeloma specifically or cancer in general,” said Golub, who is also an investigator at Howard Hughes Medical Institute and a professor of pediatrics at Harvard Medical School. “This shows that there are entirely new cancer-causing genes that are going to be discovered through these sequencing efforts.”In half of the study’s patients, the researchers found mutations in genes that control two fundamental cellular processes: how RNA is processed and how proteins are folded. Two of these genes, DIS3 and FAM46C, appear to play important roles in the stability of RNA and hence its translation into protein. Researchers also found genes involved in blood clotting mutated in multiple myeloma patients, a new and surprising discovery. Follow-up studies will be needed to understand what role these defective genes play in cancer and how they can inform treatment.“It’s going to take a lot of biological research to sort out whether these will make good drug targets,” said Golub, “but this is an example of how genetic analysis can help point the field in the right direction very dramatically.”One finding with more immediate clinical importance is the discovery of BRAF mutations in a small number of multiple myeloma patients. BRAF mutations have “never been a part of the multiple myeloma lexicon before,” according to Golub, but have been previously seen in other forms of cancer, including melanoma and colon cancer. Drugs are now in clinical development to target this particular gene and have shown promising early results in patients with melanoma.When the scientists looked at samples from more than 150 patients with multiple myeloma, they found BRAF mutations in about 4 percent of cases. Further studies will be needed to see if drugs that inhibit BRAF are as effective in patients with multiple myeloma as they have been in patients with melanoma.Golub pointed out that with more samples and the analytical tools to look genomewide, a new picture of the multiple myeloma genome is beginning to develop, and with it, new genetic insights. “This study shows that there really are entirely new cancer-causing genes that are going to be discovered through these efforts,” he said.All of the data generated through this project have been made publicly available to cancer researchers worldwide. Funding for this project was provided by the Multiple Myeloma Research Foundation, and tissue samples were provided by the Multiple Myeloma Research Consortium tissue bank.
Several St. Mary’s and Notre Dame students volunteered their time Saturday during Mahoney Family Dentistry’s second annual “Dentistry from the Heart” event, providing 297 people in the South Bend community with free dental care. Close to 200 people camped out the night before to ensure a spot for the 6 a.m. registration. A total of five local dentists and 75 volunteers, under the leadership of Dr. Terrance Mahoney, provided exams, cleanings and fillings for underprivileged citizens 18 years old and older, Dr. Mahoney said. “You get back more than you are giving and to know you can make a difference in someone’s life is so rewarding,” Dr. Mahoney said. “Access to care is the major problem in dental health care right now because many people don’t have insurance.” Dr. Mahoney said this year’s “Dentistry from the Heart” event provided close to $125,000 in dental work. The money came from both Mahoney Family Dentistry and generous donations from sponsors such as Heraeus Dental Supplies, he said. Volunteers ranged from Notre Dame seniors planning to attend dental school to parishioners of local churches, he said. Dental students from the community also gathered to provide education and advice on oral health to those waiting outside. St. Mary’s junior Kathryn Mahoney and daughter of Dr. Mahoney said she felt honored to be able to give back. “It was a great opportunity to serve the community,” Kathryn Mahoney said. “It was truly an amazing experience to see so many different people come together and help provide such an expensive necessity for absolutely free.” St. Mary’s junior and volunteer Brookelin Propestsaid it was a day well spent. “Dr. Mahoney and his office touched the lives of both the people who received the free dental care and the volunteers who witnessed it,” Propes said. “Everyone involved made a huge impact in the lives of the community.” Local businesses Einstein Bagels, Martin’s Supermarket and Papa Vino’s provided breakfast and lunch throughout the day, and Kevin’s Guitar Studio students played live entertainment throughout the afternoon. From registration at 6 a.m. to the final person served at 8 p.m., Dr. Mahoney said the day was a successful one for the community. “The people were extremely thankful and many of them shed tears of gratitude,” Dr. Mahoney said. Mahoney Family Dentistry will also be holding a free day of dental care just for children in February. Dr. Mahoney said he and his associates hope to see even more students from the Saint Mary’s and Notre Dame communities for another day of giving back.
* Your family has unexplained illnesses. Have your water tested often, Tyson said, if: High levels of such things as iron and water hardness can cause staining and laundry problems.But they don’t often affect your health. “They’re just annoyances,” he said. A water quality expert, Tyson knows a private well is a poor place to let down your guard. “Aspill of contaminants near the well could pollute your family’s drinking water supply,” he said. * You notice a change in water taste, odor, color or clarity. Many people worry most about pesticides. But Tyson said they’re way down the list ofcontaminants in Georgia. “They’re hardly ever a problem in well water,” he said. * Your neighbors find a contaminant in their water. If they’re careless, though, they can let contaminants get into the water. “You can’t have your water tested for every conceivable pollutant,” Tyson says. “But somebasic tests can tell whether you have other problems.” The keys to safe water, he said, are to be careful around the well and have your water tested asneeded. Not doing either could mean taking chances with your family’s health. * Chemicals or manure are applied to fields within 500 feet of your well. “Contact your county agent or another water quality expert to interpret test results.” Tysonsaid. “Many materials, including bacteria and nitrate-nitrogen, are naturally present in minoramounts in groundwater. Or they can vary seasonally.” “That can be a serious problem when there’s a concentration of any kind of contaminant nearthe well,” he said. “The well’s condition and nearness to contamination sources determine the risk to the wateryou drink,” said Tony Tyson, an engineer with the University of Georgia Extension Service. The best way to keep an eye on water quality, he said, is by testing your well regularly. Whenyou do, the problems you’re most likely to find are naturally occurring minerals. * Someone in the family is pregnant. Lead is another potential contaminant. It’s almost never in the groundwater. But it can be aproblem when acidic water passes through the plumbing in certain old houses. Your county Extension Service agent or health department can advise you on the correct teststo run. Testing for them isn’t often practical, since tests can cost up to $100 per compound. As a rule,test for a pesticide only if you have a reason to suspect it, such as a spill near the well. Georgia is blessed with plenty of cool, clean groundwater. About 95 percent of ruralGeorgians depend on it to supply their drinking water and farm needs. The most common problems in the rural water supply, he said, are poorly built wells thatallow surface water into the well. Then make sure you know what the test results mean. Statewide, two contaminants are the most likely to show up in rural wells. “Bacteria andnitrates,” Tyson said, can be released from septic systems, waste-storage areas, feedlots andanimal yards in amounts that could contaminate your well.”
Like many of us, credit unions are also caught up in our digital, mobile, “SnapChatty” world. It’s fun, effective and really cool. Sometimes, though, it’s easy to lose sight of being human with this digital barrier. Social media is a cool way to connect, but you’re still removed from the people or person with which you’re connecting. Mobile, too, is so convenient – texting or Facetiming on the go. Just about all of us have semi-mastered these tools, along with your credit union.So as we become more and more immersed in our digital, mobile world, how can we stay human? That’s easy on a personal level. But if you’re a credit union – or any organization, it can be a challenge. There’s one word that can open the doors to humanizing your credit union: emotion.Like any good book, movie, or play, if you can move your audience to laughter, anger, and/or tears, you’ve captured them. So let’s spin it to the financial sector. Yes, that may be a stretch, but hang on.What’s a really emotional experience that relates to finances – besides winning the lottery, finding buried treasure on a deserted island, or announcing your start-up’s IPO? But let’s face it, how many of us will experience any of these rare lightning strikes? continue reading » 20SHARESShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblr
Video Settings by Metro Unai Emery ready to put seven players up for sale as Arsenal prepare for summer clear-out SPONSORED Comment Top articles Emery post-Palace: Today we lost a big opportunityTo view this video please enable JavaScript, and consider upgrading to a web browser that supports HTML5 video Play VideoLoaded: 0%0:00Progress: 0%PlayMuteCurrent Time 0:00/Duration Time 7:36FullscreenEmery post-Palace: Today we lost a big opportunityhttps://metro.co.uk/video/emery-post-palace-today-lost-big-opportunity-1909956/This is a modal window.Beginning of dialog window. Escape will cancel and close the window.TextColorWhiteBlackRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentBackgroundColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentTransparentWindowColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyTransparentSemi-TransparentOpaqueFont Size50%75%100%125%150%175%200%300%400%Text Edge StyleNoneRaisedDepressedUniformDropshadowFont FamilyProportional Sans-SerifMonospace Sans-SerifProportional SerifMonospace SerifCasualScriptSmall CapsReset restore all settings to the default valuesDoneClose Modal DialogEnd of dialog window.Chambers has spent the season in west London at relegated Fulham, while Ospina is at Italian side Napoli.Arsenal have already cut the squad’s wage bill ahead of next season by offloading Aaron Ramsey, who is set to sign a lucrative contract with Juventus.Premier League legend Petr Cech will also retire at the end of the current campaign, while Danny Welbeck is expected to leave when his contract expires.With four league matches remaining, Arsenal are currently fifth in the Premier League, one point behind fourth-placed Chelsea who drew to Burnley on Monday.More: FootballBruno Fernandes responds to Man Utd bust-up rumours with Ole Gunnar SolskjaerNew Manchester United signing Facundo Pellistri responds to Edinson Cavani praiseArsenal flop Denis Suarez delivers verdict on Thomas Partey and Lucas Torreira moves Read More Advertisement Rio Ferdinand tells Ole Gunnar Solskjaer to drop struggling / About Connatix V67539 Visit Advertiser website GO TO PAGE Read More Read More More: FootballRio Ferdinand urges Ole Gunnar Solskjaer to drop Manchester United starChelsea defender Fikayo Tomori reveals why he made U-turn over transfer deadline day moveMikel Arteta rates Thomas Partey’s chances of making his Arsenal debut vs Man CityIt is claimed Shkodran Mustafi, who has been the subject of much criticism following Arsenal’s defeat to Crystal Palace on Sunday, will be moved on if possible.The German defender has failed to impress the Arsenal board following his £35million move from Valencia in 2016 and is enduring another difficult season.High-earners Mesut Ozil and Henrikh Mkhitaryan will also reportedly be placed in the shop window, with the Gunners keen to reduce their wage bill.Arsenal will listen to offers for out-of-favour Mohamed Elneny and Carl Jenkinson – who both started Sunday’s 3-2 loss to Palace – while Calum Chambers and David Ospina will likely be sold. Skip 1 min. story Skip Ad 1/1 Full Screen Read More Read More Coming Next Metro Sport ReporterMonday 22 Apr 2019 11:26 pmShare this article via facebookShare this article via twitterShare this article via messengerShare this with Share this article via emailShare this article via flipboardCopy link772Shares Advertisement Unai Emery is ready to sell a number of Arsenal players (Picture: Getty)Unai Emery is ready to put as many as seven players up for sale as Arsenal prepare for a summer clear-out, reports say.Emery, who replaced Arsene Wenger at the Emirates last summer, wants to bolster his squad at the end of the season but has a budget of only £45million.The Spaniard has been told, however, that he will be able to reinvest a significant proportion of any money raised from player sales.According to the Daily Mail, Emery is ready to put a number of first-team players up for sale, with the former PSG boss concerned about the quality of his current squad.AdvertisementAdvertisementADVERTISEMENT PLAY Manchester United captain Harry Maguire 
“Trustees will also need to be vigilant to less secure insurance solutions, and ensure they have performed sufficient diligence on the ability of potential providers to take on a scheme of this size.”A spokesman for the BSPS trustee board declined to comment on the Sky News report. However, Keith Greenfield, who took over as trustee chairman on 1 April this year, said in a recent member newsletter that the board was exploring its options. Keith Greenfield, chair, BSPS trusteesGreenfield said: “The priority will always be to ensure that benefits are paid in full and on time, not just today but until all benefit commitments have been met. This means the trustees need to manage the risks facing the scheme and do whatever they can to enhance the security of members’ benefits.“The board spent a lot of time last year getting a really good understanding of the risks, in conjunction with the first actuarial valuation. Exploring all available options to improve the security of members’ benefits will be a key focus for the trustee board during the coming year.”BSPS was established last year as the result of a major restructuring of the scheme, designed to stop its sponsoring company, Tata Steel, from falling into administration. The “regulated apportionment agreement”, arranged with the Pensions Regulator and the Pension Protection Fund (PPF) in 2017, helped keep the bulk of the scheme’s membership out of the PPF.The current record for the largest UK bulk annuity transfer was set by Rolls-Royce, which transferred £4.6bn to Legal & General (L&G) last month. L&G also backed the second-biggest bulk annuity transaction, a £4.4bn deal with British Airways’ Airways Pension Scheme in September 2018. The trustees of the British Steel Pension Scheme (BSPS) are exploring options for securing the benefits of the fund’s 80,800 members including an insurance buyout, according to UK media reports.Over the weekend, Sky News reported that the trustee board of BSPS was in early stage talks with insurers regarding pension risk transfer options. A full buyout of the £11.2bn (€12.5bn) scheme would be by far the largest single transaction ever conducted in the UK.Alex Hutton-Mills, managing director at covenant advisory specialist Lincoln Pensions, said such a transaction could have implications for insurers’ capacity to take on other large deals, and could affect “demand-supply dynamics and pricing” for other pension risk transfer deals.He said: “Insurers will need to balance the desire to meet the ever-expanding demand with their ability to raise additional capital, source Solvency II-compliant assets and secure adequate re-insurance (in particular for deferred members) to underwrite new policies. Some insurers will be better placed than others to find the right balance.
For local real estate agents, the return of open homes was welcomed with open arms after weeks in which virtual tours and private inspections were the only options.“It’s a big part of the way we sell property, because it gives people the chance to walk through and get a real feel for the place,” LJ Hooker Cairns Edge Hill principal Ross Moller said. “While video tours are still good, it’s not the same as coming in and seeing what it looks like, whether the ambience suits, whether the location’s good, the lay of the land, what the gardens are like and all that sort of stuff.“Buyers can get a much better feel when they can come and actually look at something.” NEW VALUE OFFER: SUBSCRIBE FOR NEWS, HEADPHONES AND MORE! OPEN TO INSPECT While nine parties had pre-registered for the open home, a further 18 turned up.Mrs Marsh said cars full of people were queuing up to check out the property.“It was somewhat chaotic trying to maintain the COVID-19 regulations, but we managed to do it,” she said. LJ Hooker Cairns Edge Hill principal Ross Moller had 15 groups through an Edge Hill unit last weekend, resulting in eight offers.More from newsCairns home ticks popular internet search terms2 days agoTen auction results from ‘active’ weekend in Cairns2 days ago“We sold it, of course,” he said.“For the right property, there’s still plenty of buyers out there.”
“We put it up online and said we’d prefer people to register in advance to allow for COVID-19 restrictions,” she said. “It was a fairly new listing in a good suburb, so we thought we’d get some people through, but certainly not what we had on the day.” Open homes are on in Cairns this weekend, including this five-bedroom luxury home in Trinity Beach from Marsh Property.It didn’t take long for real estate agents to see a spike in the number of buyer inquiries following the resumption of open home inspections.Properties will open their doors to the public again this Saturday, after the weekend tradition of open homes made its return last weekend following a six-week break due to COVID-19 restrictions. Open homes are on this weekend in Cairns.Armed with sanitiser and wearing gloves as part of COVID-19’s open home process, local agents will be hoping for another round of strong turnouts at inspections across Cairns.Marsh Property’s Deb Marsh was “blown away” by the response to the agency’s first open home at Freshwater last week. “We had four people take contracts and it was under contract a few days later, above asking price. It was a very heartening return.”She said Marsh Property would continue to “test the market” with more open homes this Saturday and any interested parties should contact the agency to pre-register, to stagger arrivals and avoid waiting times.
Lawrenceburg, In. — Highpoint Health (formerly Dearborn County Hospital) will host the facility’s 37th annual Health-A-Fair on Saturday, March 3, from 7:00 a.m. to noon at the hospital in Lawrenceburg.On Saturday, April 14, from 8:00 until 11:00 a.m., Highpoint Health will offer a second wellness event, Health-A-Fair at the Miami Center, in Cleves, Ohio. This health fair will take place at the Miami Center, 8 North Miami Avenue, on the west side of the building which houses the public library.An important additional screening, the Hemoglobin A1c (HbA1c) has been added for this year’s health fairs. Hemoglobin A1c or HbA1c is used to measure the average level of glucose in the blood over an 8-12 week period. It is commonly used to aid in the management of known diabetic patients. Recently it has become useful as a tool to help diagnose prediabetes, a risk factor for diabetes. Diagnosis of prediabetes with appropriate lifestyle and dietary changes may reduce the likelihood of full-blown diabetes developing. The fee for this screening is $30.Those wishing to have blood drawn for the HbA1c must provide the name and address of their personal physician/nurse practitioner. This information must be provided at the time of registration, whether it is at a pre-registration site or at the hospital or Miami Center on the day of the fair. Results of the analysis will be mailed to both the participant and their physician/nurse practitioner for follow-up.Both Health-A-Fairs offer a wide range of health screenings and exhibits for individuals 18 years of age and older. Some of the free health screenings offered at this year’s Health-A-Fair in Lawrenceburg include pulmonary function, blood oxygen saturation, blood pressure and height/weight. Free colorectal cancer screening kits will also be available for home use.An optional blood chemistry analysis, including an HDL/LDL cholesterol ratio, will be offered. The fee for this screening is $30.For the most accurate results, a 12 hour fast immediately before the blood chemistry analysis is recommended. Fasting for Health-A-Fair purposes is usually described as nothing to eat or drink except black coffee, plain tea, water and necessary medications. People with diabetes or those who are under a health professional’s care should consult their physician/nurse practitioner before fasting. Individuals who require food or beverages other than water to be taken with their medications during the fasting period also may wish to consult their personal physician/nurse practitioner.Health-A-Fair participants may also take part in a screening for prostate cancer. Interested men may elect to have blood drawn for a prostate specific antigen (PSA) screening at the same time blood is being obtained for the HbA1c or chemistry analysis. The fee for the PSA is $10 per person.As with the HbA1c, those wishing to have blood drawn for the chemistry analysis and/or the PSA must provide the name and address of their personal physician/nurse practitioner. This information must be provided at the time of registration. Results of these screenings will also be mailed to both the participant and their physician/nurse practitioner for follow-up.Participants are strongly encouraged to contact their personal physician/nurse practitioner regarding all of their screening results.A variety of Highpoint Health departments and services are scheduled to participate in the March 3 Health-A-Fair including the Auxiliary, Breast Care Center, Cardiac and Pulmonary Rehabilitation, Imaging/Radiology, Medical Stabilization, Occupational Health and Respiratory Therapy.Additional exhibitors include the American Cancer Society/Relay for Life, the Breast Cancer Support Group, Community Mental Health Center, Dearborn County Health Department, Lawrenceburg Public Library District, LifeCenter Organ Donor Network, LifeTime Resources, National Kidney Foundation, Purdue Extension Service, Ripley Crossing, Southeastern Indiana Alzheimer’s Support Group, the Southeastern Indiana Economic Opportunity Corporation and The Waters of Dillsboro/Ross Manor and Rising Sun.Sponsored by Highpoint Health and the Miami Center, Health-A-Fair at the Miami Center will feature many of the same screenings and exhibits found at the hospital Health-A-Fair including the blood chemistry analysis, HbA1c and the prostate-specific antigen screening.All screening results obtained at either Health-A-Fair should be used as supplemental information by the participant. They do not replace and should not be considered a substitute for an examination by a physician/nurse practitioner. Health-A-Fair participants are encouraged to share all screening results with their personal physician/nurse practitioner.Registration is available at the door at both locations, however, pre-registration is recommended. The following sites listed are for pre-registration for the Health-A-Fair at Highpoint Health on March 3. Pre-registration for the Cleves event will be held at the Miami Center in April. Click here for more information.
Betty Jean Hofstetter, 83, of Moores Hill passed away Sunday, June 17, 2018 at Highpoint Health in Lawrenceburg. Betty was born Wednesday, February 20, 1935, in Cincinnati, OH the daughter of Gladys Mae Yontz. She married Joseph D. Hofstetter March 3, 1955, and he survives. Betty was a homemaker. She was of the Mormon faith and attended Lawrenceburg Ward of LDS.Betty is survived by her husband: Joseph, son: J. Daniel (Petra) Hofstetter of Cincinnati, OH, daughters: Karen Hofstetter-Becker of Dry Ridge, KY, Diane Rene Hofstetter-Phillips of Hebron, KY , Rhea D. Hopstetter-Roy of Moores Hill, 8 grandchildren and 11 great grandchildren. She was preceded in death by one brother: Robert Yontz.Funeral services will be held at 1 p.m., Friday, June 22, 2018 at Sibbett-Moore Funeral Home with Bishop Stephen Page officiating. Burial will follow in Forest Hill Cemetery, Moores Hill. Visitation will be 12–1 pm., Friday, June 22, 2018 also at the funeral home. Memorials may be made to donor’s choice. Sibbett-Moore Funeral Home of Moores Hill entrusted with arrangements; 16717 Manchester Street, Box 156, Moores Hill, IN. You may go to www.sibbett-moore.com to leave an online condolence message for the family.
RelatedPosts Runarsson joins Arsenal on four-year deal Ighalo: My best moment as ‘Red Devil’ Arsenal, Wolves want Michael Olise Mikel Arteta secured his first win as Arsenal head coach after goals from Nicolas Pepe and Sokratis Papastathopoulos gave the Gunners a deserved 2-0 win over Manchester United at Emirates Stadium. Arsenal are still nine points adrift of fourth-placed Chelsea but they climbed into 10th place with their first Premier League home win since 6 October and have a platform to build on after overpowering Ole Gunnar Solskjaer’s side with a display brimming with energy and conviction. Arteta opted to start Pepe, Mesut Ozil, Alexandre Lacazette and Pierre-Emerick Aubameyang for the first time and that attacking quartet helped the Gunners establish early control. They scored in the fifth minute from their first attack of note. Sead Kolasinac collected Aubameyang’s pass and surged to the byline. His cut-back deflected off Daniel James’ heel into Pepe’s path and the Ivory Coast international finished low, left-footed past David de Gea. The renewed sense of purpose Arteta’s arrival delivered against Chelsea was in evidence again as Arsenal were sharper in the tackle, allowing United possession at the back before pressing with intensity and intelligence. Lacazette could have added a second just after the half-hour mark but after expertly turning Harry Maguire in the box, he could only toe-punt a left-foot shot out for a throw-in from close range. Pepe hit the post with another curling effort after De Gea gifted him possession 25 yards from goal but it was an unlikely source who eventually provided the second goal their endeavour deserved. De Gea was only able to parry Lacazette’s flick-on from Pepe’s corner into a central position and Sokratis was on hand to fire the loose ball into the roof of the net. United improved after the restart without really testing Gunners goalkeeper Bernd Leno until 18 minutes from time when substitute Mason Greenwood forced him into a smart save low to his left. However, they never looked like forcing their way back into the contest and as United lost ground on the Champions League places, Arteta was left to savour a result that he will hope is the start of a brighter future.Tags: ArsenalManchester UnitedMikel ArtetaOle Gunnar Solskjaer